/Myelin Protein Fragments (12)
/Myelin Basic Protein (85-99) Peptide Antagonist trifluoroacetate salt
產(chǎn)品詳情
Cat#：176P06
序列（三字母）：H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH trifluoroacetate salt
序列（單字母）：EKPKVEAYKAAAAPA
類似名：MBP (85-99) Peptide Antagonist
分子式：C??H???N??O??
分子量：1543.78
CAS#：444305-16-2
合成方法：Synthetic
存儲(chǔ)條件：-20 ± 5 °C
應(yīng)用：Antigen-presenting Cells|
Multiple Sclerosis
描述：The antagonistic 15-peptide EKPKVEAYKAAAAPA competes with MBP (85-99), the immunodominant epitope of myelin basic protein (MBP), a major candidate autoantigen in multiple sclerosis (MS), for binding to human leukocyte antigen (HLA)-DR2. The peptide also inhibits IL-2 secretion by MBP (85-99) specific T-cell clones and induces the production of Th2 cytokines by splenocytes. Furthermore, it could be shown that the peptide is able to suppress experimental autoimmune encephalomyelitis (EAE) in several models in a manner that is equipotent to random amino acid copolymers, such as Copaxone [poly (Y,E,A,K)n]. Therefore, this synthetic peptide might be suitable in the studying of MS.
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