產(chǎn)品詳情
Cat#：157P05
序列（三字母）：H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH trifluoroacetate salt(Disulfide bonds between Cys? and Cys12/Cys? and Cys1?)
序列（單字母）：NDDCELCVNVACTGCL
類似名：UGN Topoisomer B (human)
分子式：C??H???N??O??S?
分子量：1667.88
合成方法：Synthetic
存儲條件：-20 ± 5 °C
應(yīng)用：Gastrointestinal Research|
Obesity Research
描述：Short peptides containing two disulfide bridges can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney.
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